Filfresh 3mg Tablet

✔️ Uses of Filfresh 3mg Tablet

• Insomnia (Sleeplessness)
• Jet Lag
• Shift work sleep disorder

✔️ How does Filfresh 3mg Tablet work?

Filfresh 3mg Tablet belongs to the class of tryptophan. It works on adenylate cyclase and the blocking of a cAMP signal transduction pathway, after binding to melatonin receptor type 1A. This drug triggers phospholipase C.

✔️ Side Effects of Filfresh 3mg Tablet

• Dizziness
• Headache
• Pruritus
• Nausea
• Sleepiness
• Dizziness
• Stomach pain
• Indigestion
• Dry mouth
• Skin rash
• Chest pain
• Increased Potassium Level In the Blood

✔️ Quick Suggestions:

• Filfresh 3mg Tablet is used in the treatment of sleep disorders and also sleep-wake cycle is regulated. This medicine has melatonin as the main component. It helps you fall asleep.
• Do not take this medicine for any other condition other than that specified by your doctor. Take this medicine in the exact dose and duration as recommended. Do not take more than the prescribed dose.
• Before starting the Filfresh 3mg Tablet, consult your doctor if you are pregnant, planning on becoming pregnant, or breastfeeding, your doctor may recommend you to not use this medicine. It is not recommended for use in patients below 18 years.
• Dizziness, headache, sleepiness, nausea, or stomach pain may occur in some individuals with the use of this medicine. Inform your doctor if these effects bother you or do not go away.
• If you experience sleepiness after taking Filfresh 3mg Tablet, it is recommended to avoid driving, operating heavy machinery, or performing any such tasks that require mental alertness. It is advised to limit alcohol intake as it may increase some side effects like headache or dizziness.
• Inform your doctor if you have an autoimmune disease, diabetes, problems of the liver, or kidney, or fits, and also inform about all your other medicines and your complete medical history.
• Use of certain medicines like fluvoxamine, estrogen, quinolones, cimetidine, carbamazepine, or rifampicin along with this medicine must be avoided. It can be used only on your doctor's recommendation.

✔️ Indication of Filfresh 3mg Tablet

• Insomnia is a sleep disorder characterized by difficulty falling asleep or staying asleep. It can be caused by various factors such as poor sleeping habits, anxiety, depression, illness, lack of exercise, or certain medications. Symptoms of insomnia include trouble falling asleep, difficulty staying asleep throughout the night, and not feeling well-rested due to poor sleep quality. There are medicines available that are used to treat insomnia by helping to regulate sleep patterns and promote better sleep.
• Shift work sleep disorder is a condition where individuals who work non-traditional hours, such as night shifts or rotating shifts, experience sleeplessness and extreme sleepiness that overlap with their work schedule. This can disrupt the normal sleep-wake cycle and make it challenging to get sufficient sleep. Medicines are used in the treatment of shift work sleep disorder to help regulate sleep patterns and promote wakefulness during working hours.
• Jet lag is a temporary sleep disorder that occurs when individuals travel across multiple time zones, causing a disruption in their circadian rhythm, which is the body's natural internal clock. It can lead to sleep disturbances, fatigue, daytime tiredness, irritability, mild mental impairment, and digestive system disturbances. Medicines can be used to treat jet lag by helping to regulate sleep patterns and adjust the body's internal clock to the new time zone.

Filfresh is a medication that has potential benefits in managing sleep patterns, particularly in the short-term treatment of conditions such as jet lag. It can help regulate sleep induction in individuals with disrupted circadian rhythms, including those with jet lag, impaired vision, or those who work night shifts.

• In addition to its effects on sleep patterns, Filfresh may also have other therapeutic uses. It can be helpful in addressing melatonin deficiency, which may occur in certain populations such as the elderly and individuals with schizophrenia. It may also be used to manage insomnia in children with learning impairments.
• Filfresh has shown potential in stimulating bone-growth-promoting cells called osteoblasts, making it beneficial for individuals with osteoporosis. Additionally, it can aid perimenopausal and postmenopausal women in maintaining their sleep habits.
• There is some evidence suggesting that melatonin levels may play a role in the symptoms of anorexia nervosa, and Filfresh may have a positive impact in controlling sleep disruptions associated with this condition.

Furthermore, Filfresh may be beneficial in managing sleep disturbances in children with Attention Deficit Hyperactivity Disorder (ADHD). It may also have potential benefits in individuals with Sarcoidosis, although further research is needed to fully understand its effects in this condition.

As with any medication, it is important to consult with a healthcare professional before starting or adjusting the use of Filfresh. They can provide personalized guidance and dosage recommendations based on an individual's specific condition and needs.

✔️ Pharmacology

Melatonin acts by binding to its receptors, specifically the MT1 and MT2 receptor subtypes, after it is administered. These receptors are found in various parts of the body, including the brain. The MT1 subtype is present in the pituitary gland's pars tuberalis and the suprachiasmatic nuclei of the hypothalamus. The MT2 subtype primarily affects the retina.

When melatonin levels increase, it triggers neuronal and endocrine signals that help optimize neurotransmitter levels. This includes increasing serotonin and gamma-aminobutyric acid (GABA), while decreasing dopamine. These changes in neurotransmitter levels contribute to the induction and maintenance of sleep, as well as the regulation of the body's circadian rhythm.

By binding to melatonin receptors and influencing neurotransmitter activity, melatonin plays a crucial role in regulating sleep-wake cycles and maintaining the body's internal clock. This is why melatonin is commonly used as a supplement to address sleep disorders, such as insomnia or jet lag, and to support the adjustment of circadian rhythms in various situations.

✔️ Dosage & Administration of Filfresh 3mg Tablet

For adults:

• Insomnia: The recommended dosage is typically 3-6 mg taken one hour before bedtime.
• Jet lag: For jet lag, the dosage can vary depending on the direction of travel. For eastbound travel, a preflight early evening treatment followed by bedtime treatment for 4 days after arrival is suggested. For westbound travel, taking the medication at bedtime for 4 days in the new time zone is recommended. The dosage ranges from 0.50 to 5 mg one hour before bedtime at the final destination or 1 to 5 mg one hour before bedtime for 2 days prior to departure and for 2 to 3 days upon arrival.
• Sarcoidosis: The recommended dosage for sarcoidosis is 20 mg per day for 4 to 12 months.
• Depression: A dosage of 0.125 mg twice in the late afternoon, with each dose taken 4 hours apart, may be recommended.
• Difficulty falling asleep: In cases of difficulty falling asleep, a dosage of 5 mg is typically taken 3 to 4 hours before an imposed sleep period over a 4-week period.

For children (6 months to 14 years of age):

• Sleep disorders: The recommended dosage for sleep disorders in children is 0.30 mg per day.

It's crucial to follow the specific instructions provided by the healthcare professional and adhere to the recommended dosage and timing for the best results and to minimize potential side effects.

✔️ Interaction

Drug-Drug Interactions:

• Anti-depressant (fluvoxamine): There may be an increased risk of side effects when melatonin is taken with fluvoxamine. Close monitoring and dosage adjustments may be necessary.
• Psoralens: Melatonin may interact with psoralens, which are used to treat psoriasis. It's important to consult with a healthcare professional for appropriate timing and dosing if these medications need to be taken together.
• Antacid (cimetidine): Cimetidine may increase the blood levels of melatonin. Close monitoring may be required, and dosage adjustments may be needed.
• Hormone (estrogen): Estrogen may decrease the effectiveness of melatonin. It's advisable to consult with a healthcare professional for appropriate dosing and timing of these medications that need to be taken together.
• Antibiotic (rifampicin): Rifampicin may decrease the blood levels of melatonin. Close monitoring and dosage adjustments may be necessary.
• Anti-convulsant (carbamazepine): Carbamazepine may decrease the blood levels of melatonin. Close monitoring and dosage adjustments may be required.
• Hypnotics (midazolam, temazepam, zaleplon, zolpidem, zopiclone): There may be an increased risk of sedation and central nervous system depression when melatonin is taken with these hypnotic medications. Caution is advised, and dosage adjustments may be necessary.
• Blood thinner (warfarin): Melatonin may interact with warfarin, which can affect the blood's ability to clot. Close monitoring of clotting parameters is recommended if these medications need to be taken together.

Drug-Food Interactions:

• Smoking and alcohol consumption: Smoking and alcohol may decrease the effectiveness of melatonin or worsen its sedative effects. It's advisable to avoid smoking and limit alcohol consumption while taking melatonin.

Drug-Disease Interactions:

• Depression: Melatonin may affect mood, and caution is advised in individuals with depression. Close monitoring and regular follow-up with a healthcare professional is recommended.
• Epilepsy: Melatonin may interact with anti-convulsant medications used to treat epilepsy. Consult with a healthcare professional for appropriate dosing and monitoring.
• Autoimmune diseases: Melatonin may affect the immune system, and caution is advised in individuals with autoimmune diseases. Regular monitoring is recommended.
• Diabetes: Melatonin may affect blood sugar levels. Close monitoring of blood sugar levels is advised in individuals with diabetes.
• Glaucoma: Melatonin may increase eye pressure. Caution is advised in individuals with glaucoma, and regular eye examinations are recommended.
• Impaired liver or kidney function: Melatonin is metabolized in the liver and excreted by the kidneys. Dose adjustments may be necessary for individuals with impaired liver or kidney function. Consult with a healthcare professional for appropriate dosing recommendations.

✔️ Contraindications

• Patients with autoimmune disorders should avoid taking melatonin.
• Pregnancy and lactation
• Allergic to melatonin or any of the components

✔️ Pregnancy & Lactation

• Filfresh 3mg Tablet is not recommended for pregnant women, as there is limited information about its safety. Consult your doctor before using this tablet. Women who are of childbearing age should use contraception.
• Melatonin present in Filfresh 3mg Tablets is likely to pass into breast milk and may cause harm to your baby. Hence, this tablet is not recommended while breastfeeding. Consult your doctor before using this medicine.

✔️ Precautions & Warnings

• Allergy: If you are allergic to any of the components of Filfresh 3mg Tablet, you should avoid taking it.
• Epilepsy: Inform your doctor if you have epilepsy before taking Filfresh 3mg Tablet.
• Autoimmune diseases: It is important to inform your doctor if you have autoimmune diseases before taking Filfresh 3mg Tablet.
• Diabetes: Inform your doctor if you have diabetes before taking Filfresh 3mg Tablet.
• Impaired liver or kidney function: Inform your doctor if you have impaired liver or kidney function before taking Filfresh 3mg Tablet.
• Pregnancy: If you are pregnant, it is advisable to talk to your doctor before taking Filfresh 3mg Tablet.
• Breastfeeding: Filfresh 3mg Tablet passes into breast milk, so it is not recommended to take it while breastfeeding.
• Alcohol consumption: It is advised to avoid consuming alcohol with Filfresh 3mg Tablet as it may increase drowsiness and dizziness.

✔️ Storage Conditions

Filfresh 3mg Tablets should be stored at room temperature, protected from moisture and heat. Keep them out of reach and sight of children and pets. Do not use expired medicines. Discard unused medicines properly. Do not flush it in the toilet or throw it into the drain.